Longitudinal Change of Biomarkers in Cognitive Decline
نویسندگان
چکیده
منابع مشابه
Longitudinal change of biomarkers in cognitive decline.
OBJECTIVE To delineate the trajectories of Aβ42 level in cerebrospinal fluid (CSF), fludeoxyglucose F18 (FDG) uptake using positron emission tomography, and hippocampal volume using magnetic resonance imaging and their relative associations with cognitive change at different stages in aging and Alzheimer disease (AD). DESIGN Cohort study. SETTING The 59 study sites for the Alzheimer's Disea...
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Formal assessment of cognitive decline with cognitive tests can be difficult, requiring either two measurement points or a comparison of 'hold' with 'don't hold' tests. Informant-based assessment provides an alternative approach because informants can adopt a longitudinal perspective and directly rate cognitive change. A study was carried out to assess the validity of informant ratings collecte...
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BACKGROUND Abnormal cerebrospinal fluid (CSF) biomarker levels predict development of Alzheimer disease with good accuracy and are thought to precede cognitive deterioration. OBJECTIVE To investigate whether changes in CSF biomarker levels over time in healthy older adults are associated with a concurrent decline in cognitive performance. DESIGN Retrospective analysis of longitudinal CSF bi...
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With ever-increasing elder populations, age-related cognitive decline, which is characterized as a gradual decline in cognitive capacity in the aging process, has turned out to be a mammoth public health concern. Since genetic information has become increasingly important to explore the biological mechanisms of cognitive decline, the search for genetic biomarkers of cognitive aging has received...
متن کاملAmyloid deposition, hypometabolism, and longitudinal cognitive decline.
OBJECTIVE Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) population, we examined (1) cross-sectional relationships between amyloid deposition, hypometabolism, and cognition, and (2) associations between amyloid and hypometabolism measurements and longitudinal cognitive measurements. METHODS We examined associations between mean cortical florbetapir uptake, mean (18) F-...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2011
ISSN: 0003-9942
DOI: 10.1001/archneurol.2011.123